Upregulation of metabotropic glutamate receptor 8 mRNA expression in the rat forebrain after repeated amphetamine administration

NEUROSCIENCE LETTERS

卷:433

Article

Parelkar, Nikhil K.²  Wang, John Q.^1,2 

[1] Univ Missouri, Sch Med, Dept Basic Med Sci, Kansas City, MO 64108 USA

[2] Univ Missouri, Sch Pharm, Div Pharmacol, Kansas City, MO 64108 USA

关键词: hybridization;    dopamine;    cocaine;    cortex;    striatum;    caudate;    nucleus accumbens;   

DOI  :  10.1016/j.neulet.2008.01.015

来源: Elsevier

【 摘 要 】

Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors and are densely expressed in the forebrain of adult rats. Accumulative evidence suggests a critical role of mGluRs in the regulation of normal physiological activity of neurons and pathogenesis of mental illnesses such as schizophrenia, depression, and substance addiction. In this study, we investigated alterations in mGluR8 subtype mRNA expression in the rat forebrain in response to repeated intraperitoneal administration of amphetamine (twice daily for 12 days, 5 mg/kg per injection) using quantitative in situ hybridization. We found that mGluR8 mRNA levels were profoundly increased in the dorsal (caudate putamen) and ventral (nucleus accumbens) striatum 1 day after the discontinuation of amphetamine treatments. Such increases were sustained up to 21 days of withdrawal. Increases in mGluR8 mRNAs were also found in the cerebral cortex, including the cingulate and sensory cortex but not the piriform cortex, at 1 and 21 days. These data demonstrate a positive response of mGluR8 in mRNA abundance in most forebrain regions to repeated stimulant exposure. (C) 2008 Elsevier Ireland Ltd. All fights reserved.

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