Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

NEUROSCIENCE LETTERS

卷:437

Article

Cata, Juan P.¹  Weng, Han-Rong¹  Dougherty, Patrick M.¹ 

[1] Univ Texas MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med, Houston, TX 77030 USA

关键词: hyperalgesia;    hypalgesia;    cytokines;   

DOI  :  10.1016/j.neulet.2008.03.074

来源: Elsevier

【 摘 要 】

IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24 h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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