Role of innate immunity in chemotherapy-induced peripheral neuropathy

NEUROSCIENCE LETTERS

卷:755

Article

Uhelski, Megan L.¹  Li, Yan¹  Fonseca, Miriam M.²  Romero-Snadoval, E. Alfonso²  Dougherty, Patrick M.¹ 

[1] Univ Texas MD Anderson Canc Ctr, Div Anesthesiol Crit Care & Pain Med, Dept Pain Med Res, 1400 Holcombe Unit 409, Houston, TX 77030 USA

[2] Wake Forest Sch Med, Dept Anesthesiol, Winston Salem, NC 27101 USA

关键词: Paclitaxel;    Oxaliplatin;    Bortezomib;    TLR4;    Macrophage;   

DOI  :  10.1016/j.neulet.2021.135941

来源: Elsevier

【 摘 要 】

It has become increasingly clear that the innate immune system plays an essential role in the generation of many types of neuropathic pain including that which accompanies cancer treatment. In this article we review current findings of the role of the innate immune system in contributing to cancer treatment pain at the distal endings of peripheral nerve, in the nerve trunk, in the dorsal root ganglion and in the spinal dorsal horn.

【 授权许可】

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