fMRI differences between early and late stage-1 sleep

NEUROSCIENCE LETTERS

卷:441

Article

Picchioni, Dante¹  Fukunaga, Masaki²  Carr, Walter S.³  Braun, Allen R.⁴  Balkin, Thomas J.¹  Duyn, Jeff H.²  Horovitz, Silvina G.² 

[1] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA

[2] NINDS, Natl Inst Hlth, Bethesda, MD USA

[3] USN, Med Ctr, Bethesda, MD 20814 USA

[4] Natl Inst Deafness & Other Commun Disorders, Natl Inst Hlth, Bethesda, MD 20892 USA

关键词: fMRI;    EEG;    stage-1 sleep;    sleep scoring;    sleep onset;   

DOI  :  10.1016/j.neulet.2008.06.010

来源: Elsevier

【 摘 要 】

This study sought to test for differences in regional brain activity between stage-1 sleep immediately following wake and immediately preceding stage-2 sleep. Data were collected during daytime fMRI sessions with simultaneous EEG acquisition. A stage-1 interval was defined as follows: >= 30 s of wake, immediately followed by >= 60 s of continuous stage 1, immediately followed by >= 30 s of stage 2. We compared brain activity between the first 30 s of stage 1 (early stage 1), the last 30 s of stage 1 (late stage 1), and isolated wake. A conjunction analysis sorted each voxel into one of a series of mutually exclusive categories that represented the various possible combinations of a significant increase, decrease, or no difference among these three states. The initial dataset consisted of 14 healthy volunteers. A total of 22 sessions in these participants yielded six stage-1 intervals (from four participants) that met criteria for inclusion in the analysis. There were multiple clusters of significant voxels. Examples include changes in default-mode network areas where activity increased compared to wake only in early stage 1 and a bilateral change in the hippocampus where activity increased compared to wake only in late stage 1. These results suggest that activity in anatomically identifiable, volumetric brain regions exhibit differences during stage-1 sleep that would not have been detected with the EEG. These differences may also have specific relevance to understanding the process of sleep onset as well as the neural mechanisms of performance lapses during sleep deprivation. Published by Elsevier Ireland Ltd.

【 授权许可】

Free