New strategies for preventing epileptogenesis: Perspective and overview

NEUROSCIENCE LETTERS

卷:497

Editorial Material

Blumenfeld, Hal

关键词: Epilepsy;    Prevention;    Epileptogenesis;    Seizures;    Development;    Traumatic brain injury;    Febrile convulsions;    Treatment;    Anti-epiletogenesis;    Comorbidity;    Biomarkers;    Therapy;   

DOI  :  10.1016/j.neulet.2011.02.010

来源: Elsevier

【 摘 要 】

Epilepsy is a common disorder with a major negative impact on patient quality of life, yet treatment so far is directed mainly at blocking the symptoms-epileptic seizures, not the underlying cause. In recent years, investigation of epilepsy development or epileptogenesis has yielded new insights into potential therapies that may ultimately prevent epilepsy before it starts. In this special issue of Neuroscience Letters the latest advances in the field are brought together, summarizing: (1) important animal models in both primary and secondary epilepsies, (2) promising biomarkers for monitoring epileptogenesis, (3) cellular and molecular mechanisms which may serve as viable targets for therapy, and (4) translational approaches to human clinical trials. Bringing together these intriguing new approaches to treating epilepsy as a preventable disorder will hopefully soon make symptomatic treatment of epilepsy unnecessary in most patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free