Increased precuneus connectivity during propofol sedation

NEUROSCIENCE LETTERS

卷:561

Article

Liu, Xiaolin¹  Li, Shi-Jiang¹  Hudetz, Anthony G.² 

[1] Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA

关键词: Precuneus connectivity;    Anesthesia;    Propofol sedation;    Auditory verbal memory task;    Functional magnetic resonance imaging;   

DOI  :  10.1016/j.neulet.2013.12.047

来源: Elsevier

【 摘 要 】

Using functional magnetic resonance imaging in human participants, we show that sedation by propofol to the point of lost overt responsiveness during the performance of an auditory verbal memory task unexpectedly increases functional connectivity of the precuneus with cortical regions, particularly the dorsal prefrontal and visual cortices. After recovery of consciousness, functional connectivity returns to a pattern similar to that observed during the wakeful baseline. In the context of a recent proposal that highlights the uncoupling of consciousness, connectedness, and responsiveness in general anesthesia, the increased precuneus functional connectivity under propofol sedation may reflect disconnected endogenous mentation or dreaming that continues at a reduced level of metabolic activity. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free