Regional brain gray matter changes in adolescents with single ventricle heart disease

NEUROSCIENCE LETTERS

卷:665

Article

Singh, Sadhana¹  Kumar, Rajesh^1,2,3,4  Roy, Bhaswati⁵  Woo, Mary A.⁵  Lewis, Alan⁶  Halnon, Nancy⁷  Pike, Nancy⁵ 

[1] Univ Calif Los Angeles, Dept Anesthesiol, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dept Radiol Sci, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, UCLA Sch Nursing, Factor Bldg Room 3-232, Los Angeles, CA 90095 USA

[6] Childrens Hosp, Div Pediat Cardiol, Los Angeles, CA 90027 USA

[7] Univ Calif Los Angeles, Div Pediat Cardiol, Los Angeles, CA 90024 USA

关键词: Congenital heart disease;    Magnetic resonance imaging;    Voxel based morphometry;    Gray matter;    Cognition;   

DOI  :  10.1016/j.neulet.2017.12.011

来源: Elsevier

【 摘 要 】

Adolescents with single ventricle heart disease (SVHD) show autonomic, mood, and cognitive deficits, indicating aberrations in brain areas that regulate these functions. However, the gray matter integrity in autonomic, mood, and cognitive control sites is unclear. We examined regional brain gray matter changes, using high-resolution T1-weighted images (3.0-T magnetic resonance scanner) with voxel based morphometry procedures, as well as mood and cognitive functions in SVHD (n = 18; age, 15.7 +/- 1.1 years; male, 10) and controls (n = 31; age, 16.0 +/- 1.1 years; male, 17). High-resolution T1-weighted images were realigned, gray matter tissue type partitioned, normalized to a common space, smoothed, and compared between groups (analysis of covariance; covariates, age and gender). The mood and cognitive scores were compared between groups using independent samples t-tests. SVHD subjects showed significantly altered mood and cognitive functions over controls. Significantly reduced gray matter emerged in multiple brain areas, including the thalamus, caudate nuclei, putamen, insula, prefrontal, post-central and precentral gyrus, occipital gyrus, para-hippocampal gyros, temporal gyms, and cerebellar sites in SVHD over controls. SVHD subjects show compromised gray matter integrity in autonomic, mood and cognitive control sites. The findings indicate that frequent deficits found in SVHD subjects have a brain structural basis in the condition.

【 授权许可】

Free