Cytokine modulation in response to acute and chronic aquatic therapy intervention in Parkinson disease individuals: A pilot study

NEUROSCIENCE LETTERS

卷:674

Article

Pochmann, Daniela¹  Peccin, Pamela Krause²  Vital da Silva, Ivy Reichert¹  Dorneles, Gilson Pires³  Peres, Alessandra^1,3  Nique, Simone²  Striebel, Vera²  Elsner, Viviane Rostirola^1,2 

[1] Ctr Univ Metodista IPA, Programa Pos Grad Biociencias & Reabilitacao, Rua Coronel Joaquim Pedro Salgado 80, BR-90420060 Porto Alegre, RS, Brazil

[2] Ctr Univ Metodista IPA, Curso Fisioterapia, Porto Alegre, RS, Brazil

[3] Univ Fed Ciencias Saude Porto Alegre, Programa Pos Grad Ciencias Saude, Porto Alegre, RS, Brazil

关键词: Physiotherapy;    Inflammatory markers;    Parkinson disease;    Aquatic therapy intervention;   

DOI  :  10.1016/j.neulet.2018.03.021

来源: Elsevier

【 摘 要 】

The study aimed to compare the basal plasma levels of inflammatory markers (MCP-1, IL-1ra and IL-1 beta) in Parkinson Disease group (PDG) with control healthy subjects (control group, CG), as well to investigate the acute and chronic effects of an aquatic physiotherapy program on these biomarkers in PDG. Firstly, a rest blood sampling was taken from antecubital vein of the PD and CG. After, the PD individuals were submitted to a supervisioned aquatic physiotherapy program during 1 month, twice a week (60 min/session). In order to evaluate the acute and chronic effects of the intervention on the biomarkers, blood samples were in 4 times: before the exercise program (pre), immediately after the first session, 48 h after the exercise session and 1 month after the intervention. It was observed higher levels of the pro-inflammatory cytokines IL-1 beta and MCP-1 and reduced levels IL-1ra in PDG compared to the CG. Regarding the intervention effects in PDG, a remarkable reduction on IL-1 beta and MCP-1 levels at 48 h when compared to the basal were found. Furthermore, after 1 month, it was observed diminished levels of MCP-1 in combination to an increase on IL-1ra. Our data support the idea that an inflammatory status is linked to PD and that MCP-1 and IL-1ra could be taken as promising biomarkers in this condition. We also demonstrated that an aquatic physiotherapy program may offer a potential intervention able to attenuate immune responses in PD individuals in a short and long-term perspective.

【 授权许可】

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