Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

NEUROSCIENCE LETTERS

卷:625

Review

Bourassa, Megan W.^1,2  Alim, Ishraq^1,2  Bultman, Scott J.³  Ratan, Rajiv R.^1,2 

[1] Burke Med Res Inst, Sperling Ctr Hemorrhag Stroke Recovery, 785 Mamaroneck Ave, White Plains, NY 10605 USA

[2] Cornell Univ, Weill Med Coll, Brain & Mind Res Inst, 1300 York Ave Box 65, New York, NY 10065 USA

[3] Univ N Carolina, Dept Genet, Genetic Med Bldg,Room 5060,120 Mason Farm Rd, Chapel Hill, NC 27599 USA

关键词: Gut-brain axis;    Neuroepigenetics;    Butyrate;    High fiber diet;    Gut microbiome;   

DOI  :  10.1016/j.neulet.2016.02.009

来源: Elsevier

【 摘 要 】

As interest in the gut microbiome has grown in recent years, attention has turned to the impact of our diet on our brain. The benefits of a high fiber diet in the colon have been well documented in epidemiological studies, but its potential impact on the brain has largely been understudied. Here, we will review evidence that butyrate, a short-chain fatty acid (SCFA) produced by bacterial fermentation of fiber in the colon, can improve brain health. Butyrate has been extensively studied as a histone deacetylase (HDAC) inhibitor but also functions as a ligand for a subset of G protein-coupled receptors and as an energy metabolite. These diverse modes of action make it well suited for solving the wide array of imbalances frequently encountered in neurological disorders. In this review, we will integrate evidence from the disparate fields of gastroenterology and neuroscience to hypothesize that the metabolism of a high fiber diet in the gut can alter gene expression in the brain to prevent neurodegeneration and promote regeneration. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.

【 授权许可】

Free