Acetyl-L-carnitine enhances myelination of regenerated fibers of the lateral olfactory tract

NEUROSCIENCE LETTERS

卷:653

Article

Fukushima, Nanae¹  Yokouchi, Kumiko¹  Kuroiwa, Masafumi²  Kawagishi, Kyutaro¹  Moriizumi, Tetsuji¹ 

[1] Shinshu Univ, Sch Med, Dept Anat, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Sch Med, Dept Neurosurg, Matsumoto, Nagano 3908621, Japan

关键词: Olfactory tract injury;    Spontaneous regeneration;    Acetyl-L-carnitine;    Myelinated axons;    Neonatal rats;   

DOI  :  10.1016/j.neulet.2017.06.001

来源: Elsevier

【 摘 要 】

It is well known that acetyl-L-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases. In addition, it has been reported that ALC facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, consistently occurred in newborn rats and a majority of these regenerated fibers were unmyelinated in neonatally LOT-transected young adult rats. To investigate the effects of ALC treatment on myelination in LOT, neonatal rats were treated with ALC after LOT transection. Immunohistochemistry for myelin basic protein showed more positive areas in ALC-treated rats than in control rats. Moreover, the number of myelinated axons of regenerated fibers was assessed using electron microscopy and was found to be statistically higher in ALC-treated rats compared to control rats. The study revealed that ALC accelerates myelination of regenerated fibers in neonatally LOT-injured young adult rats. (C) 2017 Elsevier B.V. All rights reserved.

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