Projection targets of medial frontal D1DR-expressing neurons

NEUROSCIENCE LETTERS

卷:655

Article

Han, Sang-Woo¹  Kim, Young-Cho¹  Narayanan, Naridakumar S.¹ 

[1] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA

关键词: Prefrontal cortex;    Interval timing;    Dopamine receptors;   

DOI  :  10.1016/j.neulet.2017.06.057

来源: Elsevier

【 摘 要 】

Prefrontal neurons expressing DI-type dopamine receptors (D1DRs) have been implicated in a variety of cognitive processes including working memory and timing. Although D1DRs are most strongly expressed on layer V/VI projection neurons, it is unknown which brain areas are specifically targeted by these projections. Here we selectively marked D1DR neurons using cre-loxP techniques with AAV carrying mCherry fluorescent protein, and traced projection targets of D1DR+ neurons in the mouse medial frontal cortex (MFC). We found relatively strong MFC D1DR+ projections to cortical areas as well as projections to basal ganglia and thalamic nuclei. We found relatively weaker MFC D1DR+ projections to the brainstem, hypothalamus, and other subcortical nuclei. These data intimate that MFC D1DR+ projections are well positioned to powerfully influence cortical processing and have subcortical specificity. Thus MFC D1DR+ projection neurons may play a key role in tuning cortical networks during goal-directed behavior. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free