Galectin-3 is upregulated in activated glia during Junin virus-induced murine encephalitis

NEUROSCIENCE LETTERS

卷:501

Article

Jaquenod De Giusti, Carolina¹  Alberdi, Lucrecia¹  Frik, Jesica¹  Ferrer, Maria F.¹  Scharrig, Emilia¹  Schattner, Mirta²  Gomez, Ricardo M.¹ 

[1] CONICET UNLP, Biotechnol & Mol Biol Inst, La Plata, Argentina

[2] Consejo Nacl Invest Cient & Tecn, Natl Acad Med, Hematol Res Inst Mariano R Castex, Thrombosis Lab 1, RA-1033 Buenos Aires, DF, Argentina

关键词: Astrocytes;    Viral infection;    GFAP;    Microglia;   

DOI  :  10.1016/j.neulet.2011.07.007

来源: Elsevier

【 摘 要 】

Argentine haemorrhagic fever (AHF) is a systemic febrile syndrome characterized by several haematological and neurological alterations caused by Junin virus (JUNV), a member of the Arenaviridae family. Newborn mice are highly susceptible to JUNV and the course of infection has been associated with the viral strain used. Galectin-3 (Gal-3) is an animal lectin that has been proposed to play an important role in some central nervous system (CNS) diseases. In this study, we analysed Gal-3 expression at the transcriptional and translational expression levels during JUNV-induced CNS disease. We found that Candid 1 strain induced, with relatively low mortality, a subacute/chronic CNS disease with significant glia activation and upregulation of Gal-3 in microglia cells as well as in reactive astrocytes that correlated with viral levels. Our results suggest an important role for Gal-3 in viral-induced CNS disease. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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