Reduced default mode network connectivity following combat trauma

NEUROSCIENCE LETTERS

卷:615

Article

DiGangi, Julia A.^1,2  Tadayyon, Armin²  Fitzgerald, Daniel A.^1,2  Rabinak, Christine A.^3,4,5,6  Kennedy, Amy^1,2  Klumpp, Heide^2,7  Rauch, Sheila A. M.^8,9  Phan, K. Luan^1,2,7,10,11 

[1] Jesse Brown Vet Adm Med Ctr, Mental Hlth Serv Line, Chicago, IL USA

[2] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[3] Wayne State Univ, Dept Pharm Practice, Detroit, MI USA

[4] Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI 48207 USA

[5] Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI USA

[6] Wayne State Univ, Translat Neurosci Program, Detroit, MI USA

[7] Univ Illinois, Dept Psychol, Chicago, IL 60680 USA

[8] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

[9] Atlanta VA Med Ctr, Atlanta, GA USA

[10] Univ Illinois, Dept Anat & Cell Biol, Chicago, IL USA

[11] Univ Illinois, Grad Program Neurosci, Chicago, IL USA

关键词: Combat;    Trauma;    Rest;    DMN;    PTSD;    fMRI;   

DOI  :  10.1016/j.neulet.2016.01.010

来源: Elsevier

【 摘 要 】

Recent studies show decreased functional connectivity in the default mode network (DMN) in PTSD; however, few have directly examined combat trauma specifically. There is limited understanding of how combat itself may affect the DMN. Some literature suggests that trauma exposure, rather than PTSD, can disrupt the DMN. To further elucidate the effect of trauma and PTSD on the DMN, we investigated DMN functional connectivity during the resting-state in veterans with PTSD, combat-exposed controls, and never-traumatized healthy controls. Results revealed that DMN connectivity was reduced in veterans exposed to combat trauma with and without PTSD compared to healthy civilian controls. Specifically, both groups of veterans demonstrated weaker connectivity within a network involving the precuneus, medial prefrontal cortex (mPFC) and right superior parietal lobule regardless of whether the mPFC or precuneus was chosen as a seed region. Findings suggest that the experience of trauma, rather than the pathology of PTSD, may be related to DMN changes. (C) 2016 Published by Elsevier Ireland Ltd.

【 授权许可】

Free