Central administration of insulin and refeeding lead to Akt and ERK phosphorylation in the chicken medulla

NEUROSCIENCE LETTERS

卷:758

Article

Saneyasu, Takaoki¹  Ueno, Mizuki¹  Nagata, Kanami¹  Kewan, Ahmed¹  Honda, Kazuhisa¹  Kamisoyama, Hiroshi¹ 

[1] Kobe Univ, Grad Sch Agr Sci, Kobe, Hyogo 6578501, Japan

关键词: Akt;    Chickens;    ERK;    Food intake;    Hypothalamus;    Medulla;   

DOI  :  10.1016/j.neulet.2021.136008

来源: Elsevier

【 摘 要 】

The purpose of this study was to investigate whether medullary cellular signaling pathways contribute to feeding regulation in chickens. Fasting inhibited the phosphorylated protein and its rates of ERK but not Akt in the chicken medulla, while refeeding promoted Akt and ERK. Intraperitoneal administration of sulfate cholecystokinin 8 did not affect medullary Akt and ERK phosphorylation in chickens. Intracerebroventricular administration of insulin significantly induced the phosphorylation of Akt and ERK in the chicken medulla. These findings suggest that the medullary Akt and ERK pathways are involved in the appetite-suppressive pathway of insulin in chickens.

【 授权许可】

Free