Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression

NEUROSCIENCE LETTERS

卷:580

Article

Zielinski, Mark R.^1,2  Kim, Youngsoo^3,4  Karpova, Svetlana A.^1,2  McCarley, Robert W.^3,4  Strecker, Robert E.^3,4  Gerashchenko, Dmitry^1,2 

[1] Harvard Univ, Sch Med, Dept Psychiat, West Roxbury, MA 02132 USA

[2] Vet Affairs Boston Healthcare Syst, West Roxbury, MA 02132 USA

[3] Harvard Univ, Sch Med, Dept Psychiat, Brockton, MA 02301 USA

[4] Vet Affairs Boston Healthcare Syst, Brockton, MA 02301 USA

关键词: Sleep restriction;    Sleep deprivation;    Cytokine;    Interleukin-1 beta;    Tumor necrosis factor-alpha;    Brain-derived neurotropic factor;   

DOI  :  10.1016/j.neulet.2014.07.043

来源: Elsevier

【 摘 要 】

Acute sleep loss increases pro-inflammatory and synaptic plasticity-related molecules in the brain, including interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and brain-derived neurotrophic factor (BDNF). These molecules enhance non-rapid eye movement sleep slow wave activity (SWA), also known as electroencephalogram delta power, and modulate neurocognitive performance. Evidence suggests that chronic sleep restriction (CSR), a condition prevalent in today's society, does not elicit the enhanced SWA that is seen after acute sleep loss, although it cumulatively impairs neurocognitive functioning. Rats were continuously sleep deprived for 18 h per day and allowed 6 h of ad libitum sleep opportunity for 1 (SRI), 3 (SR3), or 5 (SR5) successive days (i.e., CSR). IL-1 beta, TNF-alpha, and BDNF mRNA levels were determined in the somatosensory cortex, frontal cortex, hippocampus, and basal forebrain. Largely, brain IL-1 beta and TNF-alpha expression were significantly enhanced throughout CSR. In contrast, BDNF mRNA levels were similar to baseline values in the cortex after 1 day of SR and significantly lower than baseline values in the hippocampus after 5 days of SR. In the basal forebrain, BDNF expression remained elevated throughout the 5 days of CSR, although IL-1 beta expression was significantly reduced. The chronic elevations of IL-1 beta and TNF-alpha and inhibition of BDNF might contribute to the reported lack of SWA responses reported after CSR. Further, the CSR-induced enhancements in brain inflammatory molecules and attenuations in hippocampal BDNF might contribute to neurocognitive and vigilance detriments that occur from CSR. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free