Neurological issues during COVID-19: An overview

NEUROSCIENCE LETTERS

卷:742

Article

Nath, Avindra¹  Smith, Bryan¹ 

[1] NINDS, Sect Infect Nervous Syst, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

关键词: Coronavirus;    Brain;    Neurological;    Infections;    Virus;   

DOI  :  10.1016/j.neulet.2020.135533

来源: Elsevier

【 摘 要 】

COVID-19 has shaken the core of the medical health system. The wide spread death and destruction of patients and health care workers in unprecedented in the modern era. While the pulmonary complications have received the most attention, it is the neurological manifestations that are disabling, persistent and common in patients infected with SARS-CoV-2. The entire neuro-axis can be involved resulting in a wide variety of manifestations. While the pathophysiology is not well understood, many of the clinical manifestations seem to be immune mediated. The socio-economic consequences of these complications are dire. These unprecedented times also calls for unprecedented action. Novel clinical trial designs need to be considered so that multiple agents can be studied. In the context of these clinical trials, disease pathophysiology and standardized batteries and biological markers for patient assessment need to be developed.

【 授权许可】

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