THE MICROSOMAL CALCIUM-ATPASE INHIBITOR THAPSIGARGIN IS A NEUROTOXIN IN PERINATAL RODENT BRAIN

NEUROSCIENCE LETTERS

卷:145

Article

SILVERSTEIN, FS ; NELSON, C

关键词: CALCIUM;    NEUROTOXICITY;    THAPSIGARGIN;    CALCIUM ATPASE;    PERINATAL;    RODENT;   

DOI  :  10.1016/0304-3940(92)90010-5

来源: Elsevier

【 摘 要 】

Thapsigargin is a potent inhibitor of the microsomal calcium-ATPase. We hypothesized that thapsigargin-induced liberation of calcium from sequestered intracellular sites could result in irreversible brain injury. To assess neurotoxicity, intracerebral injections of 0.1-100 nmol thapsigargin were performed in 7-day-old rats, and the severity of injury was assessed 5 days later by microscopy and measurements of lesioned areas. We found that thapsigargin elicited dose-dependent tissue injury in perinatal rodent brain.

【 授权许可】

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