Clinical neuroimaging markers of response to treatment in mood disorders

NEUROSCIENCE LETTERS

卷:669

Review

Porcu, Michele¹  Balestrieri, Antonella¹  Slott, Paolo²  Lucatelli, Pierleone³  Anzidei, Michele⁴  Suri, Jasjit S.^5,6  Zaccagna, Fulvio⁴  Argiolas, Giovanni Maria²  Saba, Luca¹ 

[1] AOU Cagliari, Dept Radiol, SS 554, Monserrato, CA, Italy

[2] Azienda Osped Brotzu, Dept Radiol, Cagliari, Italy

[3] Sapienza Univ Rome, Dept Radiol Oncol & Anatomopathol Sci, Vasc & Intervent Radiol Unit, Viale Regina Elena 324, I-00161 Rome, Italy

[4] Sapienza Univ Rome, Dept Radiol Oncol & Anatomopathol Sci, Viale Regina Elena 324, I-00161 Rome, Italy

[5] AtheroPoint, Diagnost & Monitoring Div, Roseville, CA USA

[6] Idaho State Univ Aff, Elect Engn Dept, Pocatello, ID USA

关键词: Mood disorders;    Neuroimaging;    Radiology;    MRI;    PET;   

DOI  :  10.1016/j.neulet.2016.10.013

来源: Elsevier

【 摘 要 】

Mood disorders (MD) are important and frequent psychiatric illness. The management of patients affected by these conditions represents an important factor of disability as well as a significant social and economic burden. The in-vivo studies can help researchers to understand the first developmental events of the pathology and to identify the molecular and non-molecular targets of therapies. However, they have strong limitations due to the fact that human brain circuitry can not be reproduced in animal models. In addition, these neural pathways are difficult to be selectively studied with the modern imaging (such as Magnetic Resonance and Positron Emitted Tomography/Computed Tomography) and non-imaging (such as electroencephalography, magnetoencephalography, transcranial magnetic stimulation and evoked potentials) methods. In comparison with other methods, the in-vivo imaging investigations have higher temporal and spatial resolution compared to the in-vivo non-imaging techniques. All these factors make difficult to fully understand the aetiology and pathophysiology of these disorders, and consequently hinder the analysis of the effects of pharmacological and non-pharmacological therapies, which have been demonstrated effective in clinical settings. In this review, we will focus our attention on the current state of the art of imaging in the assessment of treatment efficacy in MD. We will analyse briefly the actual classification of MD; then we will focus on the in vivo imaging methods used in research and clinical activity, the current knowledge about the neural models at the base of MD. Finally the last part of the review will focus on the analysis of the main markers of response to treatment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free