Scaling aspects of lymphocyte trafficking

JOURNAL OF THEORETICAL BIOLOGY

卷:257

Article

Perelson, Alan S.¹  Wiegel, Frederik W.² 

[1] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA

[2] Univ Amsterdam, Inst Theoret Phys, NL-1018 XE Amsterdam, Netherlands

关键词: Scaling laws;    Immunology;    Lymphocyte;    Immune repertoire;    Lymphocyte trafficking;   

DOI  :  10.1016/j.jtbi.2008.11.007

来源: Elsevier

【 摘 要 】

We consider the long lived pool of B and T cells that recirculate through blood, tissues and the lymphatic system of an animal with body mass M. We derive scaling rules (allometric relations) for: (1) the rate of production of mature lymphocytes, (2) the accumulation of lymphocytes in the tissues, (3) the flux of lymphocytes through the lymphatic system, (4) the number of lymph nodes, (5) the number of lymphocytes per clone within a lymph node, and (6) the total number of lymphocytes within a lymph node. Mass-dependent aspects of immune learning and of the immunological self are shown to be not very significant. Our treatment is somewhat heuristic and aims at combining immunological data with recent progress in biological scaling. Published by Elsevier Ltd.

【 授权许可】

Free