Negative feedback and physical limits of genes

JOURNAL OF THEORETICAL BIOLOGY

卷:284

Article

Zabet, Nicolae Radu¹ 

[1] Univ Kent, Sch Comp, Canterbury CT2 7NF, Kent, England

关键词: Auto-repression;    Output noise;    Response time;    Metabolic cost;    Trade-off;   

DOI  :  10.1016/j.jtbi.2011.06.021

来源: Elsevier

【 摘 要 】

This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost. The analysis shows that, in the case of non-vanishing leak expression rate, the negative feedback reduces both the switching on and switching off times of a gene. The noise of the auto-repressed gene will be lower than the one of the simple gene only for low leak expression rates. Summing up, for low, but non-vanishing leak expression rates, the auto-repressed gene is both faster and less noisier compared to the simple one. (c) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free