Linear noise approximation for stochastic oscillations of intracellular calcium

JOURNAL OF THEORETICAL BIOLOGY

卷:349

Article

Cantini, Laura¹  Cianci, Claudia^2,3  Fanelli, Duccio^4,5  Massi, Emma¹  Barletti, Luigi¹ 

[1] Univ Florence, Dipartimento Matemat & Informat U Dini, I-50139 Florence, Italy

[2] Univ Florence, Dipartimento Sistemi & Informat, I-50139 Florence, Italy

[3] Univ Florence, Ist Nazl Fis Nucl, I-50139 Florence, Italy

[4] Univ Florence, Dipartimento Fis & Astron, I-50019 Florence, Italy

[5] Ist Nazl Fis Nucl, I-50019 Florence, Italy

关键词: Calcium oscillations;    Goldbeter model;    Stochastic processes;    Intrinsic noise;   

DOI  :  10.1016/j.jtbi.2014.01.035

来源: Elsevier

【 摘 要 】

A stochastic model of intracellular calcium oscillations is analytically studied. The governing master equation is expanded under the linear noise approximation and a closed prediction for the power spectrum of fluctuations analytically derived. A peak in the obtained power spectrum profile signals the presence of stochastic, noise induced oscillations which extend also outside the region where a deterministic limit cycle is predicted to occur. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free