A cancer model for the angiogenic switch

JOURNAL OF THEORETICAL BIOLOGY

卷:360

Article

Viger, Louise^1,2  Denis, Fabrice³  Rosalie, Martin^1,2  Letellier, Christophe^1,2 

[1] Univ Rouen, CNRS, Normandie Univ, CORIA UMR 6614, F-76800 St Etienne du Rouvray, France

[2] INSA Rouen, F-76800 St Etienne du Rouvray, France

[3] Ctr Jean Bernard, F-72000 Le Mans, France

关键词: Endothelial cells;    Chaos;    Mathematical model;    Vascular tumor;   

DOI  :  10.1016/j.jtbi.2014.06.020

来源: Elsevier

【 摘 要 】

The occurrence of metastasis is an important feature in cancer development. In order to have a one-site model taking into account the interactions between host, effector immune and tumor cells which is not only valid for the early stages of tumor growth, we developed in this paper a new model where are incorporated interactions of these three cell populations with endothelial cells. These latter cells are responsible for the neo-vascularization of the tumor site which allows the migration of tumor cells to distant sites. It is then shown that, for some parameter values, the resulting model for the four cell populations reproduces the angiogenic switch, that is, the transition from avascular to vascular tumor. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free