Mathematical modeling in scheduling cancer treatment with combination of VEGF inhibitor and chemotherapy drugs

JOURNAL OF THEORETICAL BIOLOGY

卷:462

Article

Lai, Xiulan¹  Friedman, Avner^2,3 

[1] Renmin Univ China, Inst Math Sci, Beijing, Peoples R China

[2] Ohio State Univ, Math Biosci Inst, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Math, 231 W 18th Ave, Columbus, OH 43210 USA

关键词: Combination therapy;    Anti-VEGF;    Chemotherapy;    Scheduling;    Mathematical model;   

DOI  :  10.1016/j.jtbi.2018.11.018

来源: Elsevier

【 摘 要 】

The present paper considers a treatment of cancer with a combination of anti-VEGF (bevacizumab) and a chemotherapy drug (docetaxel). Since anti-VEGF reduces the perfusion of chemotherapy drugs, the question arises whether it is more effective to administer the two drugs at the same time, or non-overlapping, in order to reduce tumor volume more effectively. To address this question we develop a mathematical model and use it to simulate different schedules. We find that the treatment of cancer would be far more effective if the two drugs are given non-overlappingly, with the chemotherapy drug at day 0 and anti-VEGF at day 7 in cycles of 21 days. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free