Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells

JOURNAL OF THEORETICAL BIOLOGY

卷:461

Article

Dyson, Janet¹  Le Foll, Frank²  Magal, Pierre^3,4  Noussair, Ahmed^3,4  Pasquier, Jennifer^5,6 

[1] Univ Oxford, Math Inst, Oxford, England

[2] Univ Le Havre, Lab Ecotoxicol, F-76058 Le Havre, France

[3] Univ Bordeaux, IMB, UMR 5251, F-33400 Talence, France

[4] CNRS, IMB, UMR 5251, F-33400 Talence, France

[5] Qatar Fdn, Stem Cell & Microenvironm Lab, Weill Cornell Med Coll Qatar, Educ City, PO 24144, Doha, Qatar

[6] Weill Cornell Med Coll, Dept Genet Med, New York, NY USA

关键词: Indirect transfers;    Kinetic;    Quasi-linear equation;    Population dynamics models;   

DOI  :  10.1016/j.jtbi.2018.10.040

来源: Elsevier

【 摘 要 】

The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free