Noise-plasticity correlations of gene expression in the multicellular organism Arabidopsis thaliana

JOURNAL OF THEORETICAL BIOLOGY

卷:387

Article

Hirao, Koudai¹  Nagano, Atsushi J.^2,3,4  Awazu, Akinori^1,5 

[1] Hiroshima Univ, Dept Math & Life Sci, Higashihiroshima, Hiroshima 7398526, Japan

[2] Ryukoku Univ, Fac Agr, Otsu, Shiga 5202194, Japan

[3] Kyoto Univ, Ctr Ecol Res, Otsu, Shiga 5202113, Japan

[4] JST PRESTO, Kawaguchi, Saitama 3320012, Japan

[5] Hiroshima Univ, Res Ctr Math Chromatin Live Dynam, Higashihiroshima, Hiroshima 7398526, Japan

关键词: Gene expression noise;    Gene expression plasticity;    Noise-plasticity correlation;    Multicellular organism;    Arabidopsis thaliana;   

DOI  :  10.1016/j.jtbi.2015.09.017

来源: Elsevier

【 摘 要 】

Gene expression levels exhibit stochastic variations among genetically identical organisms under the same environmental conditions (called gene expression noise or phenotype fluctuation). In yeast and Escherichia coli, positive correlations have been found between such gene expression noise and plasticity with environmental variations. To determine the universality of such correlations in both unicellular and multicellular organisms, we focused on the relationships between gene expression noise and plasticity in Arabidopsis thaliana, a multicellular model organism. In recent studies on yeast and E. coli, only some gene groups with specific properties of promoter architecture, average expression levels, and functions exhibited strong noise-plasticity correlations. However, we found strong noise-plasticity correlations for most gene groups in Arabidopsis; additionally, promoter architecture, functional essentiality of genes, and circadian rhythm appeared to have only a weak influence on the correlation strength. The differences in the characteristics of noise-plasticity correlations may result from three-dimensional chromosomal structures and/or circadian rhythm. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free