An engineering thermodynamic approach to select the electromagnetic wave effective on cell growth

JOURNAL OF THEORETICAL BIOLOGY

卷:429

Article

Lucia, Umberto¹  Grisolia, Giulia¹  Ponzetto, Antonio²  Silvagno, Francesca³ 

[1] Politecn Torino, Dipartimento Energia Galileo Ferraris, Corso Duca Abruzzi 24, I-10129 Turin, Italy

[2] Univ Turin, Dipartimento Sci Med, Corso AM Dogliotti 14, I-10126 Turin, Italy

[3] Univ Turin, Dipartimento Oncol, Via Santena 5 Bis, I-10126 Turin, Italy

关键词: Extremely low-frequency electromagnetic field;    Thermodynamic approach;    Biochemical model;    Cancer cell proliferation;    Constructal law;   

DOI  :  10.1016/j.jtbi.2017.06.029

来源: Elsevier

【 摘 要 】

To date, the choice of the characteristics of the extremely low-frequency electromagnetic field beneficial in proliferative disorders is still empirical. In order to make the ELF interaction selective, we applied the thermodynamic and biochemical principles to the analysis of the thermo-chemical output generated by the cell in the environment. The theoretical approach applied an engineering bio-thermodynamic approach recently developed in order to obtain a physical-mathematical model that calculated the frequency of the field able to maximize the mean entropy changes as a function of cellular parameters. The combined biochemical approach envisioned the changes of entropy as a metabolic shift leading to a reduction of cell growth. The proliferation of six human cancer cell lines was evaluated as the output signal able to confirm the correctness of the mathematical model. By considering the cell as a reactive system able to respond to the unbalancing external stimuli, for the first time we could calculate and validate the frequencies of the field specifically effective on distinct cells. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free