Master equation approach to the assembly of viral capsids

JOURNAL OF THEORETICAL BIOLOGY

卷:242

Article

Keef, T. ; Micheletti, C. ; Twarock, R.

关键词: viral capsid assembly;    master equation;    SV40 virus;   

DOI  :  10.1016/j.jtbi.2006.04.023

来源: Elsevier

【 摘 要 】

The distribution of inequivalent geometries occurring during self-assembly of the major capsid protein in thermodynamic equilibrium is determined based on a master equation approach. These results are implemented to characterize the assembly of SV40 virus and to obtain information on the putative pathways controlling the progressive build-up of the SV40 capsid. The experimental testability of the predictions is assessed and an analysis of the geometries of the assembly intermediates on the dominant pathways is used to identify targets for anti-viral drug design. (c) 2006 Elsevier Ltd. All rights reserved.

【 授权许可】

Free