Molecular seismology: An inverse problem in nanobiology

JOURNAL OF THEORETICAL BIOLOGY

卷:246

Article

Hinow, Peter ; Boczko, Erik M.

关键词: DNA-protein interaction;    DNA binding kinetics;    single molecule studies;    wave equation;    density inversion;   

DOI  :  10.1016/j.jtbi.2006.11.013

来源: Elsevier

【 摘 要 】

The density profile of an elastic fiber like DNA will change in space and time as ligands associate with it. This observation affords a new direction in single molecule studies provided that density profiles can be measured in space and time. In fact, this is precisely the objective of seismology, where the mathematics of inverse problems have been employed with success. We argue that inverse problems in elastic media can be directly applied to biophysical problems of fiber ligand association, and demonstrate that robust algorithms exist to perform density reconstruction in the condensed phase. (c) 2006 Elsevier Ltd. All rights reserved.

【 授权许可】

Free