The impact of radiation on the development of lung cancer

JOURNAL OF THEORETICAL BIOLOGY

卷:428

Article

Li, Lingling¹  Tian, Tianhai²  Zhang, Xinan¹ 

[1] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China

[2] Monash Univ, Sch Math Sci, Melbourne, Vic 3800, Australia

关键词: Lung cancer;    Gene mutation;    Clonal expansion;    Three-stage model;    Chi-square test;   

DOI  :  10.1016/j.jtbi.2017.06.020

来源: Elsevier

【 摘 要 】

Environment factors such as radiation play an important role in the incidence of lung cancer. In spite of substantial efforts in experimental study and mathematical modeling, it is still a significant challenge to estimate lung cancer risk from radiation. To address this issue, we propose a stochastic model to investigate the impact of radiation on the development of lung cancer. The proposed three-stage model with clonal expansion is used to match the data of the male and female patients in the Osaka Cancer Registry (OCR) and Life Span Study (LSS) cohort of atomic bomb survivors in Hiroshima and Nagasaki. Our results indicate that the major effect of radiation on the development of lung cancer is to induce gene mutations for both male and female patients. In particular, for male patients, radiation affects the mutation in normal cells and the transformation from premalignant cells to malignant ones. However, radiation for female patients increases the mutation rates of the first two mutations in the stochastic model. The established relationship between parameters and radiation will provide insightful prediction for the lung cancer incidence in the radiation exposure. (C) 2017 Elsevier Ltd. All rights reserved.

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