A mathematical model of intrahost pneumococcal pneumonia infection dynamics in murine strains

JOURNAL OF THEORETICAL BIOLOGY

卷:353

Article

Mochan, Ericka¹  Swigon, David²  Ermentrout, G. Bard²  Lukens, Sarah²  Clermont, Gilles^3,4 

[1] Univ Pittsburgh, Carnegie Mellon Univ, PhD Program Computat Biol, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Math, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Dept Crit Care Med, Pittsburgh, PA 15260 USA

[4] Univ Pittsburgh, Ctr Inflammat & Regenerat Modeling, McGowan Inst Regenerat Med, Pittsburgh, PA 15260 USA

关键词: Immune response model;    Streptococcus pneumoniae infection;    Ensemble modeling;    Bacterial dynamics;   

DOI  :  10.1016/j.jtbi.2014.02.021

来源: Elsevier

【 摘 要 】

The seriousness of pneumococcal pneumonia in mouse models has been shown to depend both on bacterial serotype and murine strain. We here present a simple ordinary differential equation model of the intrahost immune response to bacterial pneumonia that is capable of capturing diverse experimentally determined responses of various murine strains. We discuss the main causes of such differences while accounting for the uncertainty in the estimation of model parameters. We model the bacterial population in both the lungs and blood, the cellular death caused by the infection, and the activation and immigration of phagocytes to the infected tissue. The ensemble model suggests that inter-strain differences in response to streptococcus pneumonia inoculation reside in the strength of nonspecific immune response and the rate of extrapulmonary phagocytosis. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free