Mathematical model of tumor-immune surveillance

JOURNAL OF THEORETICAL BIOLOGY

卷:404

Article

Mahasa, Khaphetsi Joseph¹  Ouifki, Rachid¹  Eladdadi, Amina²  de Pillis, Lisette³ 

[1] Univ Stellenbosch, DST NRF Ctr Excellence Epidemiol Modelling & Anal, Stellenbosch, South Africa

[2] Coll St Rose, Albany, NY USA

[3] Harvey Mudd Coll, Claremont, CA USA

关键词: Mathematical model;    Immune surveillance;    Tumor escape;    Immunotherapy;   

DOI  :  10.1016/j.jtbi.2016.06.012

来源: Elsevier

【 摘 要 】

We present a novel mathematical model involving various immune cell populations and tumor cell populations. The model describes how tumor cells evolve and survive the brief encounter with the immune system mediated by natural killer (NK) cells and the activated CDS+ cytotoxic T lymphocytes (CTLs). The model is composed of ordinary differential equations describing the interactions between these important immune lymphocytes and various tumor cell populations. Based on up-to-date knowledge of immune evasion and rational considerations, the model is designed to illustrate how tumors evade both arms of host immunity (i.e. innate and adaptive immunity). The model predicts that (a) an influx of an external source of NK cells might play a crucial role in enhancing NK-cell immune surveillance; (b) the host immune system alone is not fully effective against progression of tumor cells; (c) the development of immunoresistance by tumor cells is inevitable in tumor immune surveillance. Our model also supports the importance of infiltrating NK cells in tumor immune surveillance, which can be enhanced by NK cell-based immunotherapeutic approaches. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free