Mechanics of epithelial tissue formation

JOURNAL OF THEORETICAL BIOLOGY

卷:454

Article

van Drongelen, Ruben¹  Vazquez-Faci, Tania^1,2  Huijben, Teun A. P. M.¹  van der Zee, Maurijn²  Idema, Timon¹ 

[1] Delft Univ Technol, Kavli Inst Nanosci, Dept Bionanosci, Maasweg 9, NL-2629 HZ Delft, Netherlands

[2] Leiden Univ, Inst Biol, Sylviusweg 72, NL-2333 BE Leiden, Netherlands

关键词: Development;    Cellular mechanics;    Voronoi tessellation;    Biophysical modeling;   

DOI  :  10.1016/j.jtbi.2018.06.002

来源: Elsevier

【 摘 要 】

A key process in the life of any multicellular organism is its development from a single egg into a full grown adult. The first step in this process often consists of forming a tissue layer out of randomly placed cells on the surface of the egg. We present a model for generating such a tissue, based on mechanical interactions between the cells, and find that the resulting cellular pattern corresponds to the Voronoi tessellation of the nuclei of the cells. Experimentally, we obtain the same result in both fruit flies and flour beetles, with a distribution of cell shapes that matches that of the model, without any adjustable parameters. Finally, we show that this pattern is broken when the cells grow at different rates. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free