Mitochondrial energetic metabolism: A simplified model of TCA cycle with ATP production

JOURNAL OF THEORETICAL BIOLOGY

卷:258

Article; Proceedings Paper

Nazaret, Christine¹  Heiske, Margit²  Thurley, Kevin²  Mazat, Jean-Pierre³ 

[1] Univ Bordeaux 2, CNRS, IMB UMR ESTBB 5251, F-33076 Bordeaux, France

[2] Humboldt Univ, Berlin, Germany

[3] Univ Bordeaux 2, INSERM, U688, F-33076 Bordeaux, France

关键词: Mitochondria;    Energetic metabolism;    Respiratory chain;    Oxidative phosphorylation;    ATP synthase;    TCA cycle;    Dynamical system;    Existence of steady state;   

DOI  :  10.1016/j.jtbi.2008.09.037

来源: Elsevier

【 摘 要 】

Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed. (C) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

Free