Immuno-modulatory strategies for reduction of HIV reservoir cells

JOURNAL OF THEORETICAL BIOLOGY

卷:372

Article

Banks, H. T.¹  Flores, Kevin B.¹  Hu, Shuhua¹  Rosenberg, Eric^2,3  Buzon, Maria^2,3  Yu, Xu^2,3  Lichterfeld, Matthias^2,3 

[1] N Carolina State Univ, Ctr Res Sci Computat, Raleigh, NC 27695 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Mass Gen Hosp, Ragon Inst, Boston, MA USA

关键词: Immune response;    Mathematical model;    Inverse problem;    Stability analysis;   

DOI  :  10.1016/j.jtbi.2015.02.006

来源: Elsevier

【 摘 要 】

Antiretroviral therapy is able to suppress the viral load to below the detection limit, but it is not able to eradicate HIV reservoirs. Thus, there is a critical need for a novel treatment to eradicate (or reduce) the reservoir in order to eliminate the need for a lifelong adherence to antiretroviral therapy, which is expensive and potentially toxic. In this paper, we investigate the possible pharmacological strategies or combinations of strategies that may be beneficial to reduce or possibly eradicate the latent reservoir. We do this via studies with a validated mathematical model, where the parameter values are obtained with newly acquired clinical data for HIV patients. Our findings indicate that the strategy of reactivating the reservoir combined with enhancement of the killing rate of HIV-specific CD8+ T cells is able to eradicate the reservoir. In addition, our analysis shows that a targeted suppression of the immune system is also a possible strategy to eradicate the reservoir. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free