The influence of hydrostatic pressure on tissue engineered bone development

JOURNAL OF THEORETICAL BIOLOGY

卷:394

Article

Nessler, K. H. L.^1,2  Henstock, J. R.^3,4  El Haj, A. J.⁴  Waters, S. L.⁵  Whiteley, J. P.²  Osborne, J. M.^2,6 

[1] Univ Kaiserslautern, Dept Math, Postfach 3049, D-67653 Kaiserslautern, Germany

[2] Univ Oxford, Dept Comp Sci, Wolfson Bldg,Pk Rd, Oxford OX1 3QD, England

[3] Univ Liverpool, Inst Ageing & Chron Dis, Apex Bldg,West Derby St, Liverpool L7 8TX, Merseyside, England

[4] Keele Univ, Guy Hilton Res Ctr, Inst Sci & Technol Med, Thornburrow Dr, Stoke On Trent ST4 7QB, Staffs, England

[5] Univ Oxford, Math Inst, Andrew Wiles Bldg,Radcliffe Observ Quarter, Oxford 0X2 6GG, England

[6] Univ Melbourne, Sch Math & Stat, Parkville, Vic 3010, Australia

关键词: Modelling;    Tissue engineering;    Ordinary differential equation;    Biomechanical response;   

DOI  :  10.1016/j.jtbi.2015.12.020

来源: Elsevier

【 摘 要 】

The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; (i) a component describing the cell memory of the applied stimulation, and (ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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