Extra-cellular matrix rigidity may dictate the fate of injury outcome

JOURNAL OF THEORETICAL BIOLOGY

卷:469

Article

Peurichard, D.¹  Ousset, M.²  Paupert, J.²  Aymard, B.³  Lorsignol, A.²  Casteilla, L.²  Degond, P.⁴ 

[1] INRIA Paris, 2 Rue Simone Iff, F-75589 Paris 12, France

[2] Univ Toulouse, CNRS, INSERM, U1031,STROMALab,EFS,INP ENVY,UPS,ERL5311, Batiment INCERE,4 Bis Ave Hubert Curien, F-31432 Toulouse, France

[3] Inria Sophia Antipolis Mditerrane, MathNeuro Team, 2004 Route Lucioles,BP93, F-06902 Valbonne, France

[4] Imperial Coll London, Dept Math, London SW7 2AZ, England

关键词: Regeneration;    Individual-based model;    Constrained minimization;    Tissue remodeling;    Fiber insemination;   

DOI  :  10.1016/j.jtbi.2019.02.017

来源: Elsevier

【 摘 要 】

After injury, while regeneration can be observed in hydra, planaria and some vertebrates, regeneration is rare in mammals and particularly in humans. In this paper, we investigate the mechanisms by which biological tissues recover after injury. We explore this question on adipose tissue, using the mathematical framework recently developed in Peurichard et al., J. Theoret. Biol. 429 (2017), pp. 61-81. Our assumption is that simple mechanical cues between the Extra-Cellular Matrix (ECM) and differentiated cells can explain adipose tissue morphogenesis and that regeneration requires after injury the same mechanisms. We validate this hypothesis by means of a two-dimensional Individual Based Model (IBM) of interacting adipocytes and ECM fiber elements. The model successfully generates regeneration or scar formation as functions of few key parameters, and seems to indicate that the fate of injury outcome could be mainly due to ECM rigidity. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free