Implication of N-acetylglucosaminyltransferases III and V in cancer:: gene regulation and signaling mechanism

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1455

Review

Taniguchi, N ; Miyoshi, E ; Ko, JH ; Ikeda, Y ; Ihara, Y

关键词: N-acetylglucosaminyltransferase V;    N-acetylglucosaminyltransferase III;    gene regulation;    signaling;    cancer;   

DOI  :  10.1016/S0925-4439(99)00066-6

来源: Elsevier

【 摘 要 】

N-Acetylglucosaminyltransferases III (GnT-III) and V (GnT-V) play a pivotal role in the processing of N-linked glycoproteins, and are highly involved in cancer progression and metastasis. Expression of GnT-III and GnT-V in the liver is enhanced during hepatocarcinogenesis, although they are not expressed in the normal liver. Gene expression of GnT-V is regulated by a transcriptional factor, ets-l, which is involved in angiogenesis and invasion of tumor cells. When the formation of the product of GnT-V, GlcNAc-beta 1-6 branches, is inhibited by overexpression of GnT-III, lung metastasis of melanoma cells is suppressed. Modification of glycoprotein receptors such as the receptors for epidermal growth factor and nerve growth factor by GnT-III sense transfection changes an intracellular signaling pathway, which may lead to a variety of biological alterations in tumor cells. In this review, we focus on cancer progression and metastasis in relation to GnT-III and GnT-V. (C) 1999 Elsevier Science B.V. All rights reserved.

【 授权许可】

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