Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1762

Article

Smith, Karen M. ; Matson, Samantha ; Matson, Wayne R. ; Cormier, Kerry ; Del Signore, Steven J. ; Hagerty, Sean W. ; Stack, Edward C. ; Ryu, Hoon ; Ferrante, Robert J.

关键词: Huntington's disease;    coenzyme Q(10);    R6/2 transgenic mice;    therapy;    ATP;    8-hydroxy-2-deoxyguanosine;    biomarkers;   

DOI  :  10.1016/j.bbadis.2006.03.004

来源: Elsevier

【 摘 要 】

There is substantial evidence that a bioenergetic defect may play a role in the pathogenesis of Huntington's Disease (HD). A potential therapy for remediating defective energy metabolism is the mitochondrial cofactor, coenzyme Q(10) (CoQ(10)). We have reported that CoQ(10) is neuroprotective in the R6/2 transgenic mouse model of HD. Based upon the encouraging results of the CARE-HD trial and recent evidence that high-dose CoQ(10) slows the progressive functional decline in Parkinson's disease, we performed a dose ranging study administering high levels of CoQ(10) from two commercial sources in R6/2 mice to determine enhanced efficacy. High dose CoQ(10) significantly extended survival in R6/2 mice, the degree of which was dose- and source-dependent. CoQ(10) resulted in a marked improvement in motor performance and grip strength, with a reduction in weight loss, brain atrophy, and huntingtin inclusions in treated R6/2 mice. Brain levels of CoQ(10) and CoQ(9) were significantly lower in R6/2 mice, in comparison to wild type littermate control mice. Oral administration of CoQ(10) elevated CoQ(10) plasma levels and significantly increased brain levels of CoQ(9), CoQ(10), and ATP in R6/2 mice, while reducing 8-hydroxy-2-deoxyguanosine concentrations, a marker of oxidative damage. We demonstrate that high-dose administration of CoQ(10) exerts a greater therapeutic benefit in a dose dependent manner in R6/2 mice than previously reported and suggest that clinical trials using high dose CoQ(10) in HD patients are warranted. (c) 2006 Elsevier B.V. All rights reserved.

【 授权许可】

Free