Abnormal mitochondrial dynamics and neurodegenerative diseases

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1802

Review

Su, Bo¹  Wang, Xinglong¹  Zheng, Ling²  Perry, George^1,3  Smith, Mark A.¹  Zhu, Xiongwei¹ 

[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[2] Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China

[3] Univ Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA

关键词: Mitochondrial dynamics;    Mitochondrial dysfunction;    Mitochondrial distribution;    Synaptic dysfunction;    DLP1/Drp1;    Alzheimer disease;    Parkinson disease;   

DOI  :  10.1016/j.bbadis.2009.09.013

来源: Elsevier

【 摘 要 】

Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases. A deeper understanding of the remarkably dynamic nature of mitochondria, characterized by a delicate balance of fission and fusion, has helped to fertilize a recent wave of new studies demonstrating abnormal mitochondrial dynamics in neurodegenerative diseases. This review highlights mitochondrial dysfunction and abnormal mitochondrial dynamics in Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and Huntington disease and discusses how these abnormal mitochondrial dynamics may contribute to mitochondrial and neuronal dysfunction. We propose that abnormal mitochondrial dynamics represents a key common pathway that mediates or amplifies mitochondrial dysfunction and neuronal dysfunction during the course of neurodegeneration. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free