Nrf2 signaling pathway: Pivotal roles in inflammation

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1863

Review

Ahmed, Syed Minhaj Uddin¹  Luo, Lin^2,3  Namani, Akhileshwar¹  Wang, Xiu Jun²  Tang, Xiuwen¹ 

[1] Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Dept Pharmacol, Hangzhou 310058, Zhejiang, Peoples R China

[3] Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China

关键词: Nrf2;    Keap1;    ARE;    Inflammation;    Oxidative stress;    Phytochemical;   

DOI  :  10.1016/j.bbadis.2016.11.005

来源: Elsevier

【 摘 要 】

Inflammation is the most common feature of many chronic diseases and complications, while playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process by orchestrating the recruitment of inflammatory cells and regulating gene expression through the antioxidant response element (ARE).The Keap1 (Kelch-like ECH-associated protein)/Nrf2 (NF-E2 p45-related factor 2)/ARE signaling pathway mainly regulates anti-inflammatory gene expression and inhibits the progression of inflammation. Therefore, the identification of new Nrf2-dependent anti-inflammatory phytochemicals has become a key point in drug discovery. In this review, we discuss the members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-kappa B pathway. In addition we also discuss about the regulation of NLRP3 inflammasome by Nrf2. Besides this, we summarize the current scenario of the development of anti-inflammatory phytochemicals and others that mediate the Nrf2/ARE signaling pathway. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free