Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Review

Sin, Olga^1,2  Michels, Helen¹  Nollen, Ellen A. A.¹ 

[1] Univ Groningen, Univ Med Ctr Groningen, European Res Inst Biol Aging, NL-9600 AD Groningen, Netherlands

[2] Univ Porto, Abel Salazar Biomed Sci Inst, Grad Program Areas Basic & Appl Biol, P-4099003 Porto, Portugal

关键词: Caenorhabditis elegans;    Nematode;    Genetic screen;    RNAi;    EMS;    Neurodegenerative disease;    Modifier gene;   

DOI  :  10.1016/j.bbadis.2014.01.015

来源: Elsevier

【 摘 要 】

Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to humanized models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free