Targeting the telosome: Therapeutic implications

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1792

Article; Proceedings Paper

Folini, Marco¹  Gandellini, Paolo¹  Zaffaroni, Nadia¹ 

[1] Fdn IRCCS Ist Nazl Tumori, Dept Expt Oncol & Labs, I-20133 Milan, Italy

关键词: Telosome;    Telomerase;    Telomere;    G-quadruplex;    Cancer;   

DOI  :  10.1016/j.bbadis.2009.01.014

来源: Elsevier

【 摘 要 】

Since telomere integrity is required to guarantee the unlimited replicative potential of cancer cells, telomerase, the enzyme responsible for telomere length maintenance in most human tumors, and lately also telomeres themselves have become extremely attractive targets for new anticancer interventions. At the current status of knowledge, it is still not possible to define the best therapeutic target between telomerase and telomeres. It is noteworthy that interfering with telomeres, through direct targeting of telomeric DNA or proteins involved in the telosome complex, could negatively affect the proliferative potential not only of tumors expressing telomerase activity but also of those that maintain their telomeres through alternative lengthening or still unknown mechanisms. This review presents the different therapeutic approaches proposed thus far and developed in preclinical tumor models and discusses the perspectives for their use in the clinical setting. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free