Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Article

Sapojnikova, Nelly¹  Kartvelishvili, Tamar¹  Asatiani, Nino¹  Zinkevich, Vitaly²  Kalandadze, Iagor³  Gugutsidze, Darejan³  Shakarishvili, Roman³  Tsiskaridze, Alexander³ 

[1] I Javakhishvili Tbilisi State Univ, Andronikashvili Inst Phys, Tbilisi 0177, Georgia

[2] Univ Portsmouth, Sch Pharmacol & Biomed Sci, Portsmouth PO1 2DT, Hants, England

[3] I Javakhishvili Tbilisi State Univ, Fac Med, Dept Neurol & Neurosurg, Tbilisi 0179, Georgia

关键词: Human ischemic stroke;    Matrix metalloproteinases;    HMGB1;    Gelatin zymography;   

DOI  :  10.1016/j.bbadis.2014.04.031

来源: Elsevier

【 摘 要 】

Ischemic stroke (IS) outcome predictors include clinical features, biochemical parameters and some risk factors. The relations between two main players in the ischemic brain, MMPs and HMGB1, were estimated in the plasma of ischemic stroke patients stratified according to the Glasgow Outcome Scale and the Oxfordshire Community Stroke Project classification. IS patients exhibited higher plasma concentration of MMP-9 and the inflammatory cytokine HMGB1 compared with healthy controls. A full-blown correlation between MMP-9 activation and increased plasma MMP-9 concentration was observed in case of IS patients. A similar activity of MMP-2 and MMP-12 Was characteristic of healthy volunteers and IS patients. In patients with ischemic stroke increased plasma levels of MMP-9 and HMGBI are associated with a poor functional outcome and are significantly correlated with each other (P = 0.0054). We suggest that diagnostic benefits will be obtained if plasma HMGBI levels are measured for IS patients in addition to MMP-9. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

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