Embryonic programming of heart disease in response to obesity during pregnancy

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1866

Review

Ahmed, Abdalla^1,2  Delgado-Olguin, Paul^1,2,3 

[1] Hosp Sick Children, Translat Med, Toronto, ON M5G 0A4, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

[3] Heart & Stroke Richard Lewar Ctr Excellence Cardi, Toronto, ON M5S 3H2, Canada

关键词: Obesity during pregnancy;    Heart disease;    Cardiovascular disease;    Embryonic programming of disease;    Heart development;   

DOI  :  10.1016/j.bbadis.2019.01.028

来源: Elsevier

【 摘 要 】

Obesity during pregnancy programs adult-onset heart disease in the offspring. Clinical studies indicate that exposure to an adverse environment in utero during early, as compared to late, gestation leads to a higher prevalence of adult-onset heart disease. This suggests that the early developing heart is particularly sensitive to an adverse environment. Accordingly, growing evidence from clinical studies and animal models demonstrates that obesity during pregnancy alters the function of the fetal heart, programming a higher risk of cardiovascular disease later in life. Moreover, gene expression patterns and signaling pathways that promote initiation and progression of cardiovascular disease are altered in the hearts in offspring born to obese mothers. However, the mechanisms mediating the long-term effects of an adverse environment in utero on the developing heart leading to adult-onset disease are not clear. Here, we review clinical and experimental evidence documenting the effects of maternal obesity during pregnancy on the fetal and post-natal heart and emphasize on the potential mechanisms of disease programming.

【 授权许可】

Free