Telomeres do the (un)twist: Helicase actions at chromosome termini

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1792

Article; Proceedings Paper

Chavez, Alejandro^1,2,3  Tsou, Amy M.^2,3,4  Johnson, F. Brad^1,5 

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Cell & Mol Biol Grad Program, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Med Sci Training Program, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Med, Inst Aging, Philadelphia, PA 19104 USA

关键词: Telomere;    Helicase;    Senescence;    Replication;    Recombination;    G-quadruplex;   

DOI  :  10.1016/j.bbadis.2009.02.008

来源: Elsevier

【 摘 要 】

Telomeres play critical roles in protecting genome stability, and their dysfunction contributes to cancer and age-related degenerative diseases. The precise architecture of telomeres, including their single-stranded 3' overhangs, bound proteins, and ability to form unusual secondary structures such as t-loops, is central to their function and thus requires careful processing by diverse factors. Furthermore, telomeres provide unique challenges to the DNA replication and recombination machinery, and are particularly suited for extension by the telomerase reverse transcriptase. Helicases use the energy from NTP hydrolysis to track along DNA and disrupt base pairing. Here we review current findings concerning how helicases modulate several aspects of telomere form and function. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free