Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1762

Article

Schramm, C. M. ; Guernsey, L. ; Secor, E. ; Thrall, R. S.

关键词: asthma;    endotoxin;    lipopolysaccharide;    mouse;    sensitization;    tolerance;   

DOI  :  10.1016/j.bbadis.2006.02.002

来源: Elsevier

【 摘 要 】

Ovalbumin (OVA)-sensitized wildtype (WT) and endotoxin-resistant (ER) mice developed similar degrees of airways eosinophilia and serum OVA-specific IgE levels after acute acrosolized OVA challenge. WT mice demonstrated methacholine hyperreactivity, whereas ER mice showed no change in responsiveness. With chronic aerosolized OVA challenge, both WT and ER mice developed local tolerance, with resolution of airway eosinophilia but persistence of anti-OVA IgE in serum. Thus, the development of local tolerance with chronic aerosol exposure to OVA is independent of any potential effects of endotoxin in the OVA aerosol solution. (c) 2006 Elsevier B.V. All rights reserved.

【 授权许可】

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