Role of soluble adenylyl cyclase in mitochondria

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Review

Valsecchi, Federica¹  Konrad, Csaba¹  Manfredi, Giovanni¹ 

[1] Cornell Univ, Weill Med Coll, Brain & Mind Res Inst, New York, NY 10065 USA

关键词: sAC;    Mitochondria;    cAMP;    PKA;    Protein phosphorylation;   

DOI  :  10.1016/j.bbadis.2014.05.035

来源: Elsevier

【 摘 要 】

The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphmylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the activation of intra-mitochondrial PKA. In this review article, we summarize recent findings on mitochondrial sAC activation by bicarbonate (HCO3-) and calcium (Ca2+) and the effects on mitochondrial metabolism. We also discuss putative mechanisms whereby sAC-mediated mitochondrial protein phosphorylation regulates mitochondrial metabolism. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free