FGF binding proteins (FGFBPs): Modulators of FGF signaling in the developing, adult, and stressed nervous system

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1864

Article

Taetzsch, Thomas¹  Brayman, Vanessa L.^1,2  Valdez, Gregorio^1,3 

[1] Virginia Tech Caril Res Inst, Roanoke, VA USA

[2] Virginia Tech, Grad Program Translat Biol Med & Hlth, Blacksburg, VA USA

[3] Virginia Tech, Dept Biol Sci, Blacksburg, VA USA

关键词: FGFBP;    Synapse;    Neuromuscular junction;    Aging;    Diseases;    Injury;   

DOI  :  10.1016/j.bbadis.2018.06.009

来源: Elsevier

【 摘 要 】

Members of the fibroblast growth factor (FGF) family are involved in a variety of cellular processes. In the nervous system, they affect the differentiation and migration of neurons, the formation and maturation of synapses, and the repair of neuronal circuits following insults. Because of the varied yet critical functions of FGF ligands, their availability and activity must be tightly regulated for the nervous system, as well as other tissues, to properly develop and function in adulthood. In this regard, FGF binding proteins (FGFBPs) have emerged as strong candidates for modulating the actions of secreted FGFs in neural and non-neural tissues. Here, we will review the roles of FGFBPs in the peripheral and central nervous systems.

【 授权许可】

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