Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1866

Review

Scheffer, Debora da Luz¹  Latini, Alexandra¹ 

[1] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Bioquim, Lab Bioenergat & Estresse Oxidat, Campus Univ Trindade,Bloco C-201-214, BR-88040900 Florianopolis, SC, Brazil

关键词: Inflammation;    Physical exercise;    Neuroprotection;    Communicable chronic diseases;    Non-communicable chronic diseases;    Biomarker;   

DOI  :  10.1016/j.bbadis.2020.165823

来源: Elsevier

【 摘 要 】

A wide array of molecular pathways has been investigated during the past decade in order to understand the mechanisms by which the practice of physical exercise promotes neuroprotection and reduces the risk of developing communicable and non-communicable chronic diseases. While a single session of physical exercise may represent a challenge for cell homeostasis, repeated physical exercise sessions will improve immunosurveillance and immunocompetence. Additionally, immune cells from the central nervous system will acquire an anti-inflammatory phenotype, protecting central functions from age-induced cognitive decline. This review highlights the exercise-induced anti-inflammatory effect on the prevention or treatment of common chronic clinical and experimental settings. It also suggests the use of pterins in biological fluids as sensitive biomarkers to follow the anti-inflammatory effect of physical exercise.

【 授权许可】

Free