In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Review

Sesaki, Hiromi¹  Adachi, Yoshihiro¹  Kageyama, Yusuke¹  Itoh, Kie¹  Iijima, Miho¹ 

[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21218 USA

关键词: Mitochondrion;    Membrane fission;    Dynamin-related GTPase;    Neurodegeneration;    Yeast;    Mouse;   

DOI  :  10.1016/j.bbadis.2013.11.024

来源: Elsevier

【 摘 要 】

Mitochondria grow, divide, and fuse in cells. Mitochondrial division is critical for the maintenance of the structure and function of mitochondria. Alterations in this process have been linked to many human diseases, including peripheral neuropathies and aging-related neurological disorders. In this review, we discuss recent progress in mitochondrial division by focusing on molecular and in vivo analyses of the evolutionarily conserved, central component of mitochondrial division, dynamin-related protein 1 (Drp1), in the yeast and mouse model organisms. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

Free